The Tweedie Cup is contested by the member clubs of the Wigtownshire & District FA, in practice these are the thirteen South of Scotland League clubs.
The format is straight knockout.
Stranraer won the competition when it was last completed in 2017-18.
2021-22 COMPETITION (2016-17), 2017-18, 2018-19 not contested, 2019-20, 2020-21 not contested)
First Round (Nov 6)
- Caledonian Braves SOS 2-2(5-4p) Upper Annandale
- Lochmaben 4-2 Stranraer SOS
- Nithsdale Wanderers 3-1 Lochar Thistle
- St Cuthbert Wanderers 6-0 Abbey Vale
- Threave Rovers 3-7 Mid Annandale (Feb 9 @ New King Edward Park, post Nov 6)
- Creetown, Wigtown & Bladnoch, Newton Stewart – byes
Second Round (Feb 26)
- Caledonian Braves SOS 3-7 St Cuthbert Wanderers (@ St Mary’s Park)
- Mid Annandale 1-1(4-5p) Lochmaben
- Nithsdale Wanderers 1-3 Newton Stewart
- Wigtown & Bladnoch 0-3 Creetown (@ Blairmount Park)
- Lochmaben 0-3 Newton Stewart (Apr 9)
- Creetown 1-3 St Cuthbert Wanderers (Apr 13)
- Newton Stewart 1-0 St Cuthbert Wanderers (May 7 @ Trammondford Park, Wigtown)